Alternative to iodine contrast for CT colonograghy ? Some of it depends on how bad the kidney disease IS and what type. Back to top Preventing an Allergic Reaction to Contrast with Medication There are different kinds of contrast used. Rather, contrast media act to directly release histamine and other chemicals from mast cells. ... is there another alternative to this dye. Shellfish allergy has nothing to do with iodine or contrast. The increasing concerns for using gadolinium-based contrast agents in patients with renal or liver disease is urging researchers to find an alternative. Contrast media is used in radiography to increase the clarity of the image. Patients are frequently asked about iodine or seafood allergy before IV contrast material is administered because of a commonly held belief among radiologists and others in the medical community of a specific cross-reactivity between iodinated radiographic contrast material and other iodine-rich substances. locations for imaging of patients with prior history of allergy to iodine. "Iodine allergy" is often used as a collective term for adverse reactions to these agents. About Contrast Dye. Obviously speak with your physician about what to do. Computed tomography (CT) scans and magnetic resonance imaging (MRI) use different kinds of contrast. Strictly speaking, a reaction to an iodine-based dye is not the same thing as an allergy to iodine because it generally doesn’t stem from the same type of immune-system response as a true allergy. 3. Not a doctor; responding to A2A. The iodine concentration has an effect on the severity of an adverse reaction. A non-iodinated contrast media is one that does not contain iodine and may instead contain barium or other non-iodinated media as the radio opaque substance. Contrast media (sometimes called contrast agents or dye) are chemical substances used in medical X-ray, magnetic resonance imaging (MRI), computed tomography (CT), angiography, and occasionally ultrasound imaging. 4. Sometimes, contrast dye (or contrast) is used in imaging scans to help your doctors see your organs better. Iodinated contrast media are toxic to the kidneys and kidney functions. The body part with the contrast inside will appear lighter on the radiographic image than the surrounding tissue. 9. I believe there are some options out there. Author: Prof Stacy Goergen* What is contrast medium? The higher the iodine concentration, the greater the risk of an adverse reaction. Foss • • 16 Replies. The high concentration of the contrast can shock cells called basophils into releasing their granules filled with histamine. 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